Internal Medicine MCQs Posted by Pujari Vinod Date September 1, 2025 Comments 0 comment Welcome to your Internal Medicine MCQs Name Email Phone 1. Which of the following is not part of the Glasgow Coma Scale ? Eye opening Verbal response Motor response Pupillary reaction None 2. Which of the following ECG changes is a classic sign of hyperkalemia ? Tall, peaked T waves Presence of U waves ST segment depression Prolonged QT interval None 3. Which of the following is characteristic of infective endocarditis ? Chest pain Cough Hemoptysis New murmur None 4. A 72-year-old woman has new-onset atrial flutter and is hemodynamically stable. The best IV drug to control her heart rate is ? Lidocaine Aminophylline Diltiazem Magnesium None 5. Which of the following features most reliably distinguishes asthma from COPD? Chest tightness Productive cough Reversibility with bronchodilators Wheezing None 6. Which of the following does NOT cause fever of unknown origin (FUO) ? Tuberculosis Lymphoma Rheumatoid arthritis Simple viral pharyngitis None 7. In patients with atrial fibrillation, the most important reason for anticoagulation is prevention of ? Heart failure Renal failure Stroke Bleeding None 8. A patient presents with fever, malaise, and a rash. Lab examination reveals a negative Monospot test and atypical lymphocytes. Which is the most likely diagnosis ? Cytomegalovirus infection Acute HIV infection Infectious mononucleosis Scarlet fever None 9. What is the main mechanism for fasting hyperglycemia in type 2 diabetes ? Decreased peripheral glucose uptake Increased hepatic glucose production Compensatory hyperinsulinemia Impaired insulin secretion None 10. A 40-year-old woman presents with chronic diarrhea and a serum anti-tissue transglutaminase antibody. Diagnosis is ? Celiac disease Ulcerative colitis Irritable bowel syndrome Crohn’s disease None 11. Which of the following antihypertensive agents is contraindicated in pregnancy ? Methyldopa Hydralazine ACE inhibitors Labetalol None 12. In a patient with acute MI, the earliest ECG change is ? Pathological Q waves Tall T waves T wave inversion ST elevation None 13. The earliest sign of papilledema due to raised intracranial pressure is ? Sixth nerve palsy Loss of optic cup Visual obscurations Papilledema None 14. The classic symptom triad of diabetic ketoacidosis (DKA) includes ? Confusion, blurred vision, cough Polyuria, polydipsia, and weight loss Fever, joint pain, rash Nausea, vomiting, constipation None 15. The first-line treatment for hypertension in a diabetic patient with proteinuria is ? Beta-blocker Calcium channel blocker ACE inhibitor Thiazide diuretic None 16. Which electrolyte imbalance is most commonly associated with digoxin toxicity? Hypocalcemia Hypokalemia Hypercalcemia Hyperkalemia None 17. In a hospitalized patient with a new fever and Systemic Inflammatory Response Syndrome (SIRS) criteria, which of the following tests is most commonly ordered first? Serum ferritin Liver function tests Cardiac enzymes Blood cultures None 18. Which of the following is NOT a feature of nephrotic syndrome ? Hematuria Hyperlipidemia Hypoalbuminemia Edema None 19. Which of the following antibiotics is most appropriate for treating a life-threatening Methicillin-Resistant Staphylococcus aureus infection ? Vancomycin Gentamicin Penicillin Erythromycin None 20. Which of the following is the most common cause of persistent fever with chills in a patient from India ? Malaria Enteric fever Tuberculosis Leptospirosis None 21. A 6-year-old boy presents with periorbital edema and frothy urine. The most likely diagnosis is ? Acute glomerulonephritis Nephrotic syndrome Urinary tract infection Renal tubular acidosis None 22. Which of the following is required to confirm the diagnosis of diabetes mellitus? 2-hour glucose during OGTT ≥200 mg/dL HbA1c ≥6.5% Fasting plasma glucose ≥126 mg/dL All of the above None 23. Which of the following is the most common cause of community-acquired pneumonia in adults? Staphylococcus aureus Haemophilus influenzae Streptococcus pneumoniae Mycoplasma pneumoniae None 24. Which investigation is most useful for confirming deep vein thrombosis ? Ultrasound Doppler D-dimer CT scan Venography None 25. The best screening test for colorectal cancer is ? Barium enema Fecal occult blood test Colonoscopy CT scan None 26. Which of the following is true regarding initial therapy for type 2 diabetes mellitus(except renal failure patients) ? Start with sulfonylurea for all Start with insulin for all Start with metformin Start with SGLT2 inhibitor None 27. The primary defect in cystic fibrosis involves ? Chloride channels Potassium channels Sodium channels Calcium channels None 28. A patient with chronic renal failure has a hemoglobin of 8 g/dL. The most appropriate treatment is ? Blood transfusion Erythropoietin Iron supplements Vitamin B12 None 29. Which test is best for evaluating unexplained fever in the hospital setting ? Urinalysis Blood culture All of the above Chest X-ray None 30. All of the following are classic symptoms of myocardial infarction EXCEPT ? Diaphoresis Polyuria Shortness of breath Chest pain None Share: Pujari Vinod Previous post Critical Care MCQs September 1, 2025 Next post Fellowship in Pediatrics October 7, 2025 You may also like Fellowships without NEET PG: A credible career path for MBBS doctors January 22, 2026 Fellowship Courses After MBBS in India: A Practical Career Guide December 26, 2025 Top International Certification Programs for Indian Doctors June 5, 2025