Internal Medicine MCQs Posted by Dr Vinod Date September 1, 2025 Comments 0 comment Welcome to your Internal Medicine MCQs Name Email Phone 1. What is the main mechanism for fasting hyperglycemia in type 2 diabetes ? Decreased peripheral glucose uptake Impaired insulin secretion Compensatory hyperinsulinemia Increased hepatic glucose production None 2. The most common cause of acute pancreatitis is ? Alcohol Viral infection Hypercalcemia Gallstones None 3. Which ECG change is considered highly specific for acute pericarditis ? PR depression ST elevation (diffuse) QRS widening QT prolongation None 4. Which is the most sensitive test for early diabetic nephropathy ? 24-hour urine protein Microalbuminuria Serum creatinine Ultrasound None 5. Which of the following is the most common cause of persistent fever with chills in a patient from India ? Leptospirosis Enteric fever Malaria Tuberculosis None 6. Which one of the following is NOT a recognized complication of myocardial infarction ? Diabetes insipidus Pericarditis Left ventricular aneurysm Arrhythmias None 7. The earliest sign of papilledema due to raised intracranial pressure is ? Visual obscurations Papilledema Loss of optic cup Sixth nerve palsy None 8. Which of the following is required to confirm the diagnosis of diabetes mellitus? HbA1c ≥6.5% All of the above 2-hour glucose during OGTT ≥200 mg/dL Fasting plasma glucose ≥126 mg/dL None 9. The best screening test for colorectal cancer is ? Fecal occult blood test Colonoscopy Barium enema CT scan None 10. The classic symptom triad of diabetic ketoacidosis (DKA) includes ? Fever, joint pain, rash Confusion, blurred vision, cough Polyuria, polydipsia, and weight loss Nausea, vomiting, constipation None 11. The primary defect in cystic fibrosis involves ? Potassium channels Chloride channels Calcium channels Sodium channels None 12. Which of the following is true regarding initial therapy for type 2 diabetes mellitus(except renal failure patients) ? Start with insulin for all Start with SGLT2 inhibitor Start with metformin Start with sulfonylurea for all None 13. Which investigation is most useful for confirming deep vein thrombosis ? CT scan D-dimer Venography Ultrasound Doppler None 14. Which of the following is NOT a risk factor for coronary artery disease ? Hypertension Hypothyroidism Smoking Hyperlipidemia None 15. The most sensitive investigation for detecting intracranial hemorrhage acutely is ? MRI CT scan Lumbar puncture EEG None 16. Which clinical finding is most associated with suspected hypertensive emergency ? BP 180/105 mmHg with headache BP 160/90 mmHg in a young adult BP 200/120 mmHg with papilledema and confusion BP 130/85 mmHg with mild ankle edema None 17. Which ECG finding is most specific for acute pericarditis ? U waves Diffuse ST elevation T wave inversion Q waves None 18. Which of the following ECG changes is a classic sign of hyperkalemia ? Presence of U waves Tall, peaked T waves Prolonged QT interval ST segment depression None 19. Which of the following is NOT used to treat tuberculosis ? Rifampin Ivermectin Pyrazinamide Isoniazid None 20. The first-line treatment for hypertension in a diabetic patient with proteinuria is ? ACE inhibitor Calcium channel blocker Thiazide diuretic Beta-blocker None 21. Which of the following is characteristic of infective endocarditis ? Hemoptysis Chest pain Cough New murmur None 22. A patient with chronic liver disease is most likely to die from ? GI hemorrhage Renal failure Liver failure Infection None 23. A 6-year-old boy presents with periorbital edema and frothy urine. The most likely diagnosis is ? Renal tubular acidosis Urinary tract infection Acute glomerulonephritis Nephrotic syndrome None 24. The best initial management for acute gout is ? Colchicine Corticosteroids NSAIDs Allopurinol None 25. A 55-year-old man presents with polyuria, polydipsia, and weight loss. Lab findings show hyperglycemia and glycosuria. The most likely diagnosis is ? Type 2 diabetes mellitus Diabetes insipidus Type 1 diabetes mellitus Cushing’s syndrome None 26. Which of the following is NOT a feature of nephrotic syndrome ? Hyperlipidemia Hypoalbuminemia Hematuria Edema None 27. Which of the following features most reliably distinguishes asthma from COPD? Chest tightness Reversibility with bronchodilators Wheezing Productive cough None 28. Which of the following is the most common cause of community-acquired pneumonia in adults? Haemophilus influenzae Streptococcus pneumoniae Mycoplasma pneumoniae Staphylococcus aureus None 29. Which of the following does NOT cause fever of unknown origin (FUO) ? Rheumatoid arthritis Lymphoma Tuberculosis Simple viral pharyngitis None 30. A 72-year-old woman has new-onset atrial flutter and is hemodynamically stable. The best IV drug to control her heart rate is ? Diltiazem Magnesium Aminophylline Lidocaine None Share: Dr Vinod Previous post Critical Care MCQs September 1, 2025 Next post Fellowship in Pediatrics October 7, 2025 You may also like Is Working in a Tier 2 City Actually Better for Indian Doctors in 2026? July 28, 2026 India’s ICU Capacity Crisis : What It Means for Doctors and Patients in 2026 July 27, 2026 Fellowship Courses Without NEET PG: A credible career path for MBBS doctors January 22, 2026
